Symbol
Name
ID

Trp53
transformation related protein 53
MGI:98834

Phenotype annotations related to cardiovascular system

*	Aspects of the system are reported to show a normal phenotype.
!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes	Central retinal vessel vascular tortuosity	Premature coronary artery atherosclerosis	Hypertension	Arrhythmia	Sudden cardiac death	Myocardial infarction	Congestive heart failure	Lymphadenopathy	Splenomegaly	Hepatosplenomegaly
Disease(s) Associated with TP53	Central retinal vessel vascular tortuosity	Premature coronary artery atherosclerosis	Hypertension	Arrhythmia	Sudden cardiac death	Myocardial infarction	Congestive heart failure	Lymphadenopathy	Splenomegaly	Hepatosplenomegaly
coronary artery disease
Graves' disease
Leber hereditary optic neuropathy
multiple myeloma
pancreatic cancer

Mouse Phenotypes

cardiovascular system phenotype

abnormal retina vasculature morphology

increased angiogenesis

abnormal cardiac outflow tract development

persistent truncus arteriosus

abnormal atrioventricular cushion morphology

double outlet right ventricle

ventricular septal defect

increased heart weight

enlarged heart

cardiac hypertrophy

abnormal cardiovascular system physiology

hemorrhage

abnormal response to cardiac infarction

vascular inflammation

Availability

Mouse Genotype

Trp53^bhy/Trp53^bhy

Trp53^tm1.1Manf/Trp53^tm1.1Manf

Trp53^tm1.1Tldo/Trp53^tm1.1Tldo

Trp53^tm1.2Awbr/Trp53^tm1.2Awbr

Trp53^tm1Brd/Trp53^tm1Brd

Trp53^tm1Tyj/Trp53^tm1Tyj

Trp53^tm2Wahl/Trp53^tm2Wahl

Trp53^tm1.1Tldo/Trp53⁺

Trp53^tm1.2Awbr/Trp53⁺

Trp53^tm1Brd/Trp53⁺

Trp53^tm1Brn/Trp53^tm1Brn
Tg(Upk2-cre)1Rkl/0 (conditional)

Tg(CMV-cre)1Cgn/0
Trp53^tm4Att/Trp53⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23